jueves, 15 de marzo de 2012

Difference between NSAID and acetaminophen

So, I've always known that Aspirin and Tylenol weren't the same exactly, but I really never understood why. And when I did, I would often forget the difference. Here's the breakdown:

Non-steroidal anti-inflammatory drug (Aspirin):
  • reduces pain
  • reduces fever
  • reduces inflammation
  • causes stomach irritation/damage (biggest disadvantage of this medication)
    • inhibits the production of prostaglandins --> inhibits protection against acidity
    • prostaglandins
      • local hormones that transmit pain information to the brain
      • modulate hypothalamic thermostat
      • activate inflammatory response
      • stimulates constriction and clotting of platelets
      • involved with induction of labor
      • involved with GI tract (inhibits acid synthesis and increases secretion of protective mucus)
      • increases blood flow in kidneys
      • bronchoconstrictor (used for asthma)
  • reduces blood clot formation
    • Aspirin is the only NSAID with an antiplatelet effect 
  • Common types: Aspirin, Ibuprofen, Naproxen, Advil, Toradol, Motrin
    • These drugs differ in their mechanism of action, although they accomplish the same task

Acetaminophen/Paracetamol (Tylenol):
  • reduces pain
  • reduces fever
  • not indicated for anti-inflammatory purposes because it exhibits weak anti-inflammatory activity
  • does NOT reduce blood clot formation
  • better tolerated in those with gastric acid problems
  • Common types: Tylenol, Genapap, Feverall, Actamin, Altenol, Aminofen, Anacin Aspirin Free, Apra


Sources:
  • Aspirin is NOT acetaminophen
  • Acetaminophen = A for Analgesic!

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