Non-steroidal anti-inflammatory drug (Aspirin):
- reduces pain
- reduces fever
- reduces inflammation
- causes stomach irritation/damage (biggest disadvantage of this medication)
- inhibits the production of prostaglandins --> inhibits protection against acidity
- prostaglandins
- local hormones that transmit pain information to the brain
- modulate hypothalamic thermostat
- activate inflammatory response
- stimulates constriction and clotting of platelets
- involved with induction of labor
- involved with GI tract (inhibits acid synthesis and increases secretion of protective mucus)
- increases blood flow in kidneys
- bronchoconstrictor (used for asthma)
- reduces blood clot formation
- Aspirin is the only NSAID with an antiplatelet effect
- Common types: Aspirin, Ibuprofen, Naproxen, Advil, Toradol, Motrin
- These drugs differ in their mechanism of action, although they accomplish the same task
Acetaminophen/Paracetamol (Tylenol):
- reduces pain
- reduces fever
- not indicated for anti-inflammatory purposes because it exhibits weak anti-inflammatory activity
- does NOT reduce blood clot formation
- better tolerated in those with gastric acid problems
- Common types: Tylenol, Genapap, Feverall, Actamin, Altenol, Aminofen, Anacin Aspirin Free, Apra
Sources:
- http://www.elmhurst.edu/~chm/vchembook/555prostagland.html
- http://www.ncbi.nlm.nih.gov/pubmed/6208802
Mnemonics to help:
- Aspirin is NOT acetaminophen
- Acetaminophen = A for Analgesic!
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